Menu

We independently review everything we recommend. When you buy through our links, we may earn a commission at no additional cost to you. Learn more ›

Best FRONTLINE®BrandProducts Flea Treatments

FRONTLINE® Plus offers effective topical flea and tick treatments for dogs of all sizes and cats, killing fleas, ticks, and preventing infestations with veterinarian-recommended formulas.

5 products

Select a Product

Click on a product from the list to view its details.

PRIME

ProductReviews.org score rating is a scoring system developed by our experts. The score is from 0 to 10 based on the data collected by the ProductReviews.org tool. This score doesn't impact from any manufacturer or sales agent websites. We encourage you to write a review of your experiences with these products. Learn more »
Last update on . Affiliate links, prices, images, product titles, and highlights from Amazon Product Advertising API.

Pros

Cons

Key Features

User Reviews

Your review will be visible after approval.

Loading reviews...
FRONTLINE Plus Flea & Tick Treatment for X-Large Dogs 89-132 lbs | Waterproof, Kills Fleas Eggs Ticks Lice, 3 Doses

FRONTLINE Plus is a waterproof topical flea and tick treatment for X-Large dogs (89-132 lbs) that kills fleas, eggs, larvae, chewing lice, and Lyme-carrying ticks for 30 days per dose. Its standout quality is breaking the flea life cycle with fipronil and (S)-methoprene; buy it for owners of large breed dogs needing proven, monthly protection.

  • Provides full-month waterproof protection against fleas, ticks, and lice
  • Breaks the flea life cycle by killing eggs and larvae to prevent reinfestation
  • Fast-acting formula trusted by pet owners for over 20 years
  • Safe for puppies 8 weeks old and 5 lbs or more
  • Easy one-spot application spreads across entire body via skin glands

Kills multiple flea stages and ticks that carry Lyme disease. Long-lasting 30-day protection per dose. Simple monthly topical application.

Requires monthly reapplication for continuous protection. Not suitable for dogs under 89 lbs or cats. Application site may feel greasy initially.

FRONTLINE Plus for Medium Dogs 23-44 lbs: Waterproof Flea & Tick Killer, Kills Eggs & Larvae, 3 Doses

FRONTLINE Plus is a topical flea and tick treatment for medium dogs 23-44 lbs that kills adult fleas, eggs, larvae, lice, and Lyme-carrying ticks. Its waterproof formula provides 30-day protection and breaks the flea life cycle, ideal for owners of puppies 8 weeks and older seeking trusted, easy-to-apply prevention.

  • Breaks the flea life cycle by killing fleas, eggs, and larvae for complete infestation control
  • Waterproof protection lasts a full 30 days, even if your dog swims or gets bathed
  • Fast-acting against ticks that transmit Lyme disease, chewing lice, and more
  • Safe and easy to apply on puppies 8 weeks old and 5+ lbs with one monthly dose
  • Trusted by pet owners for over 20 years of proven flea and tick defense

Highly effective at killing multiple flea and tick life stages. Long-lasting waterproof formula for active dogs. Simple monthly application for consistent protection.

Requires monthly reapplication to maintain protection. Topical application may feel greasy initially. Not intended for use on cats.

FRONTLINE Plus for Cats Flea & Tick Treatment - Waterproof, Kills Fleas Eggs Larvae Ticks - 3 Doses Over 1.5 lbs

FRONTLINE Plus is a topical flea and tick treatment for cats and kittens over 1.5 lbs and 8 weeks old, providing 30-day waterproof protection that kills adult fleas, eggs, larvae, chewing lice, and ticks including those transmitting Lyme disease. Its dual active ingredients break the flea life cycle, making it ideal for cat owners needing reliable monthly prevention.

  • Delivers waterproof, 30-day protection against fleas, ticks, and lice
  • Breaks the flea life cycle by killing eggs and larvae to prevent reinfestation
  • Kills ticks that may transmit Lyme disease for comprehensive safety
  • Fast-acting formula trusted by pet owners for over 20 years
  • Safe for kittens 8 weeks and older weighing 1.5 pounds or more

Proven to kill fleas at all life stages plus ticks and lice. Long-lasting waterproof protection for a full month. Effective on young kittens from 8 weeks old.

For cats only; separate formula needed for dogs. Requires monthly reapplication for ongoing protection. Topical application may temporarily greasy fur.

FRONTLINE Plus for Large Dogs 45-88 lbs: Waterproof Flea Tick Killer, Kills Eggs Larvae, 3 Doses

FRONTLINE Plus is a waterproof topical flea and tick treatment for large dogs 45-88 lbs that kills fleas, eggs, larvae, chewing lice, and Lyme-carrying ticks for 30 days per dose. Dog owners needing reliable, #1 trusted flea life cycle protection for medium-large breeds should buy this 3-treatment pack.

  • Provides 30-day waterproof protection against fleas, ticks, and lice for worry-free outdoor adventures
  • Breaks the flea life cycle by eliminating eggs and larvae to prevent reinfestations
  • Trusted #1 brand for over 20 years, safe for puppies 8 weeks and older
  • Easy one-spot monthly application spreads across your dog's entire body
  • Kills ticks that transmit Lyme disease for comprehensive health defense

Fast-acting formula kills adult fleas and prevents new infestations. Long-lasting reservoir in sebaceous glands works even if dog gets wet. Proven effective on large dogs with simple monthly dosing.

Requires monthly reapplication for continuous protection. Sized specifically for 45-88 lb dogs, not suitable for smaller or larger pets. Topical application may feel greasy initially.

FRONTLINE Plus for Small Dogs 5-22 lbs: Waterproof Flea Tick Killer, Kills Eggs Larvae Lice, 3 Doses Puppies 8 Weeks+

FRONTLINE Plus is a topical flea and tick treatment for dogs 5-22 lbs, proven to kill fleas, eggs, larvae, chewing lice, and Lyme-carrying ticks for 30 days per waterproof dose. Trusted for over 20 years, it's ideal for owners of small dogs and puppies 8 weeks and older needing reliable, easy-to-apply monthly protection.

  • Provides full 30-day waterproof protection against fleas, ticks, eggs, larvae, and lice
  • Breaks the flea life cycle to prevent reinfestations and guard your home
  • Safe and effective for puppies as young as 8 weeks old weighing 5 lbs or more
  • Easy one-spot application spreads across the entire body via natural oils
  • Trusted by pet owners for over 20 years of proven flea and tick control

Fast-acting waterproof formula works even after swimming or bathing. Kills a broad spectrum of pests including those transmitting Lyme disease. Simple monthly dosing ensures consistent, long-lasting results.

Requires monthly reapplication to maintain protection. Topical application may feel greasy initially on pet's fur. Not for dogs under 5 lbs or younger than 8 weeks.

Protecting your furry friends from fleas and ticks is essential for their health and happiness, and FRONTLINE® Plus delivers reliable, veterinarian-recommended topical treatments tailored to dogs of every size and cats. This category features 3-dose packs for small dogs (5-22 lbs), medium dogs (23-44 lbs), large dogs (45-88 lbs), extra-large dogs (89-132 lbs), and cats over 1.5 lbs, making it easy to find the perfect fit for your pet's needs.

Why FRONTLINE® Plus Stands Out in Flea Control

FRONTLINE® has built a stellar reputation over decades as a leader in pet parasite protection, thanks to its science-backed formulas that target fleas, ticks, flea eggs, and larvae at multiple life stages. Unlike some alternatives, these treatments spread via the pet's natural oils for full-body coverage, remain waterproof after 24-48 hours, and provide up to 30 days of protection. They're safe for puppies as young as 8 weeks and kittens over 1.5 lbs when used as directed, earning trust from millions of pet owners and vets alike.

Choosing the Right FRONTLINE® Plus for Your Pet

Selecting the ideal treatment starts with your pet's weight, as each formula is precisely dosed for safety and efficacy. For small dogs up to 22 lbs, the compact applicator ensures easy application without waste. Medium dogs (23-44 lbs) benefit from balanced coverage, while large (45-88 lbs) and extra-large (89-132 lbs) options handle bigger breeds with robust protection against heavy infestations.

Cats get their own specialized version, formulated to be gentle yet powerful on feline skin. All packs contain 3 monthly treatments, perfect for consistent year-round use, even in flea-prone seasons. Key features to consider include:

  • Flea and tick kill plus prevention: Eliminates adult pests and stops reproduction.
  • Waterproof design: Stays effective through baths and swims.
  • Easy spot-on application: Dries quickly with no mess.
  • Vet-endorsed safety: Proven for multi-pet households.

If fleas persist or your dog has sensitivities, consult your vet, but these treatments shine in everyday prevention for active pets.

Comparing FRONTLINE® Plus Across Sizes

While all variants share the same active ingredients—fipronil and (S)-methoprene—the difference lies in dosage volume matched to weight. Small and medium dog treatments suit apartment dwellers with pint-sized pups, offering precise control. Large and XL packs are ideal for breeds like Labs or Great Danes, tackling outdoor exposures. Cat treatments avoid dog-specific strengths, preventing overdosing risks.

For multi-pet homes, stocking size-specific packs simplifies routines. Compared to broader Flea Treatments options, FRONTLINE® excels in longevity and broad-spectrum action, outperforming some budget choices in independent tests.

When to Use FRONTLINE® Plus Treatments

Ideal for year-round prevention in flea hotspots or after vet-diagnosed infestations. Apply monthly between the shoulder blades for best absorption. Pair with home cleaning for complete control. Pet owners exploring alternatives might check Advantage Flea Treatments for egg-focused formulas or K9 Advantix II for mosquito repellent, but FRONTLINE® leads in tick protection. Backed by a trusted name, it's a staple in Flea & Tick Control.

Frequently Asked Questions

How do I choose the right FRONTLINE® Plus size for my dog?

Match your dog's current weight to the label: small (5-22 lbs), medium (23-44 lbs), large (45-88 lbs), or XL (89-132 lbs). Reapply based on weight changes, and use the cat version only for felines over 1.5 lbs.

Is FRONTLINE® Plus safe for pregnant or nursing pets?

Yes, it's generally safe when used as directed, but always consult your veterinarian for breeding, pregnant, or lactating pets to ensure suitability.

How does FRONTLINE® compare to other brands like PetArmor?

FRONTLINE® offers superior tick control and longer-lasting waterproofing versus generics like PetArmor Flea Treatments, with a stronger track record in vet clinics.

What if I need treatments for puppies or kittens?

Puppies 8 weeks+ and 5+ lbs can use the small dog formula; kittens over 1.5 lbs and 8 weeks use the cat version. Younger pets require vet guidance.

Does FRONTLINE® offer customer support or warranty?

FRONTLINE® provides robust support via their website, including application tips and satisfaction guarantees on select purchases—contact them for specifics.

Keep your pets flea-free with FRONTLINE® Plus, the gold standard in topical protection. Explore more in our Topical Treatments or Dogs sections for comprehensive care.